PB2 Mutation in Swine Flu

Two genetic sequences were recently releasedpeople cough, they're not shedding as much virus
from the Netherlands that detail a PB2 mutation inas they could if an equal amount (or more) of the
the AH1N1 flu in two unrelated individuals. Thevirus was located in the nose and throat.
significance of this mutation, the E627K, is that itThis mutation may be linked to an increasing
allows the flu to replicate more effectively indeath rate in the Americas and India, where
colder temperatures, at about 90 degreesmany clinicians thought that the flu was mutating
Fahrenheit. The temperature of your nose in theand becoming more deadly. This may or may not
Winter, for example.be the case, but it is a definite possibility.
Since this mutation allows the virus to replicateThere is another mutation that is note worthy
more effectively there, people will start receivingand may have a significant influence on the flu and
larger viral loads from coughs and sneezes, whichhas been showing increasing prevalence. You've
can lead to more serious illness in those effected.probably heard of this one, but it's Tamiflu
This mutation has, generally, been linked toresistance. The number of cases has been
increased virulence and transmissibility. Think: theincreasing and many have been linked to a
current flu is most effective in the lungs, whichparticular mutation that is fit to become
explains why most cases are of mild illness. It'swidespread. Be on the lookout for Tamiflu
not easy for a virus to reach the lungs, given theresistance in your area!
fact that they're so deep in the body. So when