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Septic Shock - Definition, Causes, Symptoms and Treatment

Septic shock is a serious medical endotoxins which trigger the release of
condition. During septic shock, the body inflammatory mediators which causes
tissues and organs do not get enough vasodilation and increase in capillary
blood and oxygen. Septic shock may permeability leading to shock.
progress to cause "adult respiratory Septic shock is a medical emergency.
distress syndrome," in which fluid Prompt treatment of bacterial infections
collects in the lungs, and breathing is helpful. Septic shock is treated
becomes very shallow and labored. Septic initially with a combination of
shock occurs most often in the very old antibiotics and fluid replacement.
and the very young. It also occurs in Treatment primarily consists of
people who have other illnesses. Serious antimicrobial chemotherapy, removal of
bacterial infections at any body site, the source of infection, and
with or without bacteremia, usually are haemodynamic, respiratory, and metabolic
associated with important changes in the support. Coagulation and hemorrhage may
function of every organ system in the be treated with transfusions of plasma or
body. Septic shock can lead to multiple platelets. Dopamine may be given to
organ failure including respiratory increase blood pressure further if
failure, and may cause rapid death. Toxic necessary. High doses of intravenous
shock syndrome is one type of septic antibiotics are given as soon as blood
shock. Septic shock is usually preceded samples have been taken for laboratory
by bacteremia, which is marked by fever, cultures. Surgery may be performed to
malaise, chills, and nausea. The first remove any dead tissue, such as
sign of shock is often confusion and gangrenous tissue of the intestine.
decreased consciousness. Bacteremia may Despite all efforts, more than 25% of
be primary (without an identifiable focus people with septic shock die.
of infection) or, more often, secondary Corticosteroid therapy appears
(with an intravascular or extravascular beneficial. Treatment is with
focus of infection). replacement, rather than pharmacologic,
Septic shock occurs more often in doses. Scrupulous aseptic technique on
neonates, patients > 35 yr, and pregnant the part of medical professionals lowers
women. Septic shock is severe sepsis with the risk of introducing bacteria into the
organ hypoperfusion and hypotension that bloodstream.
are poorly responsive to initial fluid Treatment for Septic Shock Tips
resuscitation. The condition develops as 1. Antimicrobial chemotherapy, removal of
a response to certain microbial molecules the source of infection, and
which trigger the production and release haemodynamic, respiratory, and metabolic
of cellular mediators, such as tumor support.
necrosis factors. Toxic shock syndrome 2. Corticosteroids, especially if
most often occurs in menstruating women combined with a mineralocorticoid, can
using highly absorbent tampons. It occurs reduce mortality among patients.
in about 40% of patients with 3. Activated protein C can reduce
gram-negative bacteremia and in about 20% mortality in patients with multi-organ
of patients with Staphylococcus aureus failure.
bacteremia. Hyperventilation with 4. Coagulation and hemorrhage may be
respiratory alkalosis occurs early, in treated with transfusions of plasma or
part as compensation for lactic acidemia. platelets.
Serum HCO3 is usually low, and serum and 5. Dopamine may be given to increase
blood lactate increase. One of the major blood pressure further if necessary.
causes of the condition leading to septic 6. Surgery may be performed to remove any
shock is infection by gram negative dead tissue, such as gangrenous tissue of
organism. The cell walls contain the intestine.




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